One might be able to argue that Dane Cook or Nickelback’s success is funny, but one of the big taboos in comedy is cancer. You typically don’t see much humor derived from an ailment that affects millions each year. Screenwriter Will Reiser though effectively manages to take the topic of cancer and turn it into a honest, genuine, and surprisingly funny look on the craziness surrounding an already terrible predicament in 50/50. Joseph Gordon-Levitt plays Adam, essentially a stand-in for Reiser, who learns he has a rare form of cancer along his spine in the peak of his life. Seth Rogen, from reports who basically plays himself as he did to Reiser, is the supportive, opportunistic, and (of course) foul-mouthed friend to help along the way. We also meet Adam’s super-supportive girlfriend Rachel (Bryce Dallas Howard), his overbearing mother (Anjelica Huston), and his new-to-the-field therapist (Anna Kendrick) as they try and support Adam though the diagnosis, treatment, and aftermath. ...